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Newven (Desvenlafaxine 100mg)

Newven general information

What is Newven used for?

Newven tablets 100mg are used to treat major depression and symptoms of depressive illness, including anxiety, loss of interest in usual activities, disturbed sleep, change in appetite, fatigue, feelings of worthlessness or guilt, difficulty thinking or concentrating, and recurrent thoughts of suicide.  Newven tablets 100mg are also used to treat other mood disorders that affect daily activities and relationships with others including, social anxiety disorder (Social Phobia), panic disorder (panic attacks) and generalised anxiety disorder.   Newven tablets 100mg help manage the emotional and physical symptoms of depression to help improve ability to function at work, in family and social life and in leisure activities.

How does Newven work?

Newven tablets 100mg contain desvenlafaxine which is the active metabolite of venlafaxine, an antidepressant belonging to the class of drugs known as Serotonin-Noradrenaline Reuptake Inhibitors (SNRIs), but is structurally and chemically different to other antidepressants.  Desenlafaxine in Newven tablets 100mg acts in the brain to correct the chemical imbalance caused by a lack of certain neurotransmitters (brain chemical that allows nerve cells to communicate) that is thought to be one of the major causes of depression and other mood disorders, particularly a lack of serotonin, which controls many body activities, including regulating mood.  Desvenlafaxine is a potent inhibitor of the reuptake of serotonin and noradrenaline, and also weakly inhibits dopamine reuptake, which means that it blocks the re-uptake of serotonin and noradrenaline from the synapse (the gap between nerve cells across which chemical messages are sent from one nerve cell to another).  If the re-uptake of serotonin and noradrenaline by the first nerve cell (pre-synaptic) is blocked, this means that there is more neurotransmitter remaining for the receiving nerve cell (post-synaptic), which allows nerve cells to communicate with each other for longer.  The action of Newven tablets 100mg helps relieve symptoms of depression and other mood disorders by increasing the amount of serotonin and noradrenaline in the brain, which in turn increases stimulation of nerve pathways that control mood.  Newven tablets 100mg are formulated so that desvenlafaxine is released slowly into the digestive system for extended-release of the medication, to allow for a single dose per day.

What does Newven contain?

Newven tablets 100mg contain the active ingredient desvenlafaxine, an antidepressant belonging to the Serotonin-Noradrenaline Reuptake Inhibitors (SNRIs) that are used to treat depression and other mood disorders. 

Treating depression with Newven

Newven tablets 100mg contain desvenlafaxine which is the active metabolite of venlafaxine, an antidepressant belonging to the class of drugs known as Serotonin-Noradrenaline Reuptake Inhibitors (SNRIs).  Newven tablets 100mg are used to treat symptoms of depression, including anxiety, loss of interest in usual activities, disturbed sleep, change in appetite, fatigue, feelings of worthlessness or guilt, difficulty thinking or concentrating and recurrent thoughts of suicide.  One of the major causes of depression is thought to be an imbalance of neurotransmitters (brain chemicals that allows nerve cells to communicate), particularly a lack of serotonin that controls mood.  Desenlafaxine in Newven tablets 100mg works by specifically blocking the reuptake of serotonin and noradrenaline from the synapse, or gap between nerve cells across which chemical messages are sent to allow nerve cell to communicate with each other.  By preventing the reuptake of serotonin and noradrenaline by the first nerve cell (pre-synaptic) there is more neurotransmitter remaining for the receiving nerve cell (post-synaptic), so that nerve cells can communicate with each other for longer which increases stimulation of nerve pathways that control mood changes, relieving symptoms of depression. 

What are the side effects of Newven?

The most commonly reported side effects when taking Newven tablets 100mg include: decreased or loss of appetite, dry mouth, diarrhoea, nausea, constipation, sleeplessness, fatigue, drowsiness, increased sweating, vasodilation (hot flashes), hypertension (increase in blood pressure), sexual problems.

When should Newven not be used?

You should not use Newven tablets 100mg if you:

  • are allergic to desvenlafaxine or any ingredients in Newven
  • are pregnant or are breastfeeding
  • have liver disease
  • have a recent history of myocardial infarction or unstable heart disease
  • are taking any monoamine oxidase inhibitor medications (such as phenelzine and tranylcypromine) as these can cause serious reactions if taken with Newven or within 14 days
  • are taking medicines that interact with Newven monoamine oxidase inhibitors (MAOIs) for depression, other antidepressants, the analgesic tramadol, tryptophan, or phentermine (weight-reducing medicines), sumatriptan for migraine, the antipsychotic pimozide, herbal remedies containing St. John´s Wort, bupropion, for nicotine dependence, the antifungal ketoconazole, the antibiotic erythromycin, clozapine for schizophrenia
  • are taking medication that affects blood clotting as these may increase risk of bleeding if taken with Newven

What medications interact with Newven?

Several medications interact with Newven tablets 100mg and should either not be taken while you are taking Newven or only after discussion and instruction from your doctor:

  • Drugs that cause a serious reaction with Newven: monoamine oxidase inhibitors (MAOIs) like phenelzine and tranylcypromine for depression, medication that affects blood clotting like warfarin
  • Drugs that affect Newven: the analgesic tramadol, tryptophan, or phentermine (weight-reducing medicines), sumatriptan for migraine, St John's wort, a herbal remedy used to treat mood disorders, cimetidine for reflux and ulcers , antifungal ketoconazole, the antibiotic erythromycin
  • Drugs that are affected by Newven: the antidepressants lithium and Imipramine, clozapine for schizophrenia, the anticoagulant warfarin

How should Newven be taken?

You should take your Newven tablets 100mg with a glass of water, swallowed whole with or without food You should take your Newven tablets 100mg swallowed whole with a glass of water, with or without food once a day, at the same time each day.  Your doctor may increase your dose, depending on what you are being treated for.  You should continue take your Newven tablets 100mg for as long as recommended by your doctor, depending on your condition and your doctor’s recommendations, usually for several weeks or months and you should continue your medication even if you feel well. 

How long should you take Newven?

You should continue take your Newven tablets 100mg for as long as recommended by your doctor, depending on your condition and your doctor’s recommendations, usually for several weeks or months and you should continue your medication even if you feel well.

Missed dose of Newven

If you miss a dose of Newven tablets 100mg take it as soon as you remember, unless it is time to take the next dose, then skip the missed dose.  Do not take a double dose.

How should Newven be stored?

You should store your Newven tablets 100mg below 25°C in a cool dry place. 

 

Phenergan 25mg (Promethazine)

Phenergan general information

What is Phenergan used for?

Phenergan tablets 25mg are used to treat a variety of allergic conditions, including allergic contact dermatitis, allergic reactions to drugs, hives (urticaria), and bites and stings, to relieve symptoms of redness, swelling and itching of the skin; also to relieve upper respiratory tract symptoms of allergic rhinitis, including nasal congestion, runny itchy nose and sneezing, caused by seasonal allergies like hayfever. Phenergan tablets 25mg are also used as an antiemetic to reduce nausea and vomiting due to several conditions including postoperative vomiting, irradiation sickness, drug-induced nausea and motion sickness. Phenergan tablets 25mg have sedative properties, which can be used to help with management of the symptoms of measles and chicken pox; also for short-term sedation.

How does Phenergan work?

Phenergan tablets 25mg contain promethazine, an antihistamine belonging to phenothiazine group of drugs that also has antiemetic (prevents nausea) and sedative properties. Histamine is a chemical released from mast cells, (cells involved in allergies) as part of the body’s defence mechanism during an allergic reaction. Histamine and binds to H1 receptors in small blood vessels causing them to leak, allowing white blood cells and blood proteins into the tissues. These infiltrating cells produce inflammatory chemicals (prostaglandins and leukotrienes) that cause tissue swelling and irritation, which are symptoms of an allergic reaction. Promethazine in Phenergan tablets 25mg is an H1 receptor antagonist and works by binding to histamine receptors and blocking the action of histamine without blocking its secretion. This action blocks histamine-mediated allergic reactions, relieving symptoms in the upper respiratory tract like nasal congestion, runny itchy nose and sneezing, and in the skin like redness, swelling and itching. Promethazine in Phenergan tablets 25mg also acts on the central nervous system (CNS). Some brain neurones (nerve cells) produce histamine and the action of histamine in the brain is involved in stress and anxiety reactions. Blocking these brain histamine receptors is thought to be responsible for causing sedation. The same CNS mechanism is also responsible for the anti-emetic effect of Phenergan tablets 25mg. Motion sickness is caused by conflicting information being received by the brain from the eyes and the vestibular system in the inner ear; messages sent by the ear suggest motion, whereas the messages sent by the eye suggest that the body is still. The conflicting information received into the brain stimulates the vomiting centre of the brain to induce the vomiting reflex. Promethazine in Phenergan tablets 25mg binds to histamine receptors on cells of the vestibular apparatus of the inner ear and is also thought to bind to histamine receptors on nerve cells in the brain to block the transmission of nerve impulses from the inner ear to the vomiting center in the brain, which in turn prevents transmission of nerve signals from the brain to receptors in the stomach, so that the vomiting reflex is blocked.

What does Phenergan contain?

Phenergan tablets 25mg contain the active ingredient promethazine hydrochloride, an antihistamine belonging to phenothiazine group of drugs that also has antiemetic (prevents nausea) and sedative properties. They also contain lactose, starch maize, povidone, magnesium stearate, hypromellose, macrogol 200, blue opaspray.

Treating allergy with Phenergan

Phenergan tablets 25mg contain the antihistamine promethazine, which is used to relieve symptoms of allergy in several allergic conditions, including allergic contact dermatitis, allergic reactions to drugs, hives (urticaria), bites and stings; also allergic rhinitis caused by seasonal allergies like hayfever. Histamine is a chemical released from mast cells, (cells involved in allergies) as part of the body’s defence mechanism during an allergic reaction and binds to H1 receptors in small blood vessels causing them to leak, allowing white blood cells and blood proteins into the tissues. These infiltrating cells produce inflammatory chemicals (prostaglandins and leukotrienes) that cause tissue swelling and irritation, which are symptoms of an allergic reaction. Promethazine in Phenergan tablets 25mg is an H1 receptor antagonist and works by binding to histamine receptors and blocking the action of histamine without blocking its secretion. This action blocks histamine-mediated allergic reactions, relieving symptoms in the upper respiratory tract like nasal congestion, runny itchy nose and sneezing, and in the skin like redness, swelling and itching.

Treating motion sickness with Phenergan

Phenergan tablets 25mg contain promethazine, an antihistamine that is used to control the nausea and vomiting associated with motion sickness caused by all forms of travel including, air, sea train or car travel. The inner ear contains the vestibular apparatus, comprising the membranous labyrinth structures of the cochlea and semicircular canals, where motion or changes in the body’s position is detected and continual information about body position is transmitted to the brain. Motion causes the endolymph (fluid that fills the inner ear) to trigger electrical signals via special sensory cells sending nerve impulses via neurotransmitters (chemicals that allow nerve cells to communicate) along the auditory nerve to the brain to be interpreted. Motion sickness is caused by conflicting information being received by the brain from the eyes and the vestibular system; messages sent by the ear suggest motion, whereas the messages sent by the eye suggest that the body is still. The conflicting information received into the brain stimulates the area postrema or vomiting centre of the brain to induce the vomiting reflex. Promethazine in Phenergan tablets 25mg binds to histamine receptors on cells of the vestibular apparatus of the inner ear and is also thought to bind to histamine receptors on nerve cells in the brain and this blocks the transmission of nerve impulses from the inner ear to the vomiting center in the brain, which in turn prevents transmission of nerve signals from the brain to receptors in the stomach, so that the vomiting reflex is blocked. Phenergan tablets 25mg are also used to reduce nausea and vomiting due to several conditions including postoperative vomiting, irradiation sickness and drug-induced nausea.

Phenergan for sedation

Phenergan tablets 25mg contain promethazine, an antihistamine that has sedating properties. Promethazine in Phenergan tablets 25mg is an H1 receptor antagonist and works by binding to histamine receptors in various parts of the body including the brain. Some brain neurones (nerve cells) produce histamine and the action of histamine in the brain is involved in stress and anxiety reactions. Blocking these brain histamine receptors is thought to be responsible for causing sedation.

What are the side effects of Phenergan?

The most commonly reported side effects when taking Phenergan tablets 25mg include: dry mouth, gastro-intestinal disturbances (diarrhoea, constipation, nausea, vomiting or abdominal pain) loss of appetite, tiredness, sleepiness, restlessness, dizziness, blurred vision.

When should Phenergan not be used?

You should not use Phenergan tablets 25mg if you:
  • are allergic to promethazine or any ingredients in Phenergan
  • are allergic to sulphites, benzoates or phenothiazines
  • are pregnant or are breastfeeding
  • have had jaundice induced by other phenothiazine derivatives
  • are taking medicines that interact with Phenergan, including: monoamine oxidase inhibitors (MAOIs) (up to 14 days previously), tricyclic antidepressants, sedatives and hypnotics, opioid analgesics, barbiturates
Phenergan tablets 25mg should not be used for children under 2 years or for anyone in a coma.

What medications interact with Phenergan?

Several medications interact with Phenergan tablets 25mg to increase side effects and can cause a serious reaction and should either not be taken while you are taking Phenergan or only after discussion and instruction from your doctor: including: monoamine oxidase inhibitors (MAOIs) (up to 14 days previously, tricyclic antidepressants, sedatives and hypnotics, opioid analgesics, barbiturates.

How should Phenergan be taken?

You should take your Phenergan tablets 25mg swallowed whole with a glass of water. The dose you take and how often depends on what you are being treated for and your doctor’s recommendation. For allergy and sedation you should take your Phenergan tablets 25mg at night. For travel sickness you should take one tablet the night before travel and you can take another dose the next day, provided 6-8 hours has elapsed. For nausea and vomiting you should take your Phenergan tablets 25mg every 4 to 6 hours as recommended by your doctor. You should continue to take your Phenergan tablets 25mg for as long as your symptoms persist, or as recommended by your doctor but for no longer than 10 consecutive days.

How long should you take Phenergan?

You should continue to take your Phenergan tablets 25mg for as long as your symptoms persist, or as recommended by your doctor but for no longer than 10 consecutive days.

Missed dose of Phenergan

If you miss a dose of Phenergan tablets 25mg take it as soon as you remember, unless it is time to take the next dose, then skip the missed dose. Do not take a double dose.

How should Phenergan be stored?

You should store your Phenergan below 25°C in a cool dry place.



Itrabond (Itraconazole) 100mg

Itrabond general information

What is Itrabond used for?

Itrabond capsules 100mg are used to treat a variety of superficial and systemic fungal infections in various parts of the body.  Fungal infections that Itrabond 100 is used for include:

  • Persistent infections of the skin with pityriasis versicolor, which is caused by the yeast-like fungus malassezia and characterised by rash and patches of flaky skin on the trunk, neck or arms.
  • Persistent infections with the fungus tinea (also called ringworm) in various parts of the body including the body (tinea corporis), foot (tinea pedis) and groin (tinea cruris or jock itch).
  • Candidiasis (thrush) of the mucus membranes such as in the mouth and vagina, also of the skin.
  • Persistent infections of the vagina with the yeast candida (candidiasis).
  • Infection of the nail (onychomycosis) with yeast or dermatophyte fungi like tinea.
  • Fungal keratitis, an infection of the cornea of the eye by mould fungi like aspergillus or the yeast Candida, resulting in inflammation.
  • Systemic fungal infections that can affect internal organs such as histoplasmosis a rare systemic fungal infection from inhalation of a soil fungus into the lung causing flu-like symptoms; also aspergillosis, a lung infection caused by breathing in spores of the mould fungus aspergillus.  These systemic fungal infections are more common in people who are immunocompromised.

How does Itrabond work?

Itrabond capsules 100mg contain itraconazole broad-spectrum antifungal drug belonging to the triazole group of antifungals.  Itraconazole in Itrabond capsules 100mg is a potent and specific inhibitor of fungal enzymes necessary for the synthesis of ergosterol, an important component of fungal cell membrane that is not found in animal cells.  A lack of ergosterol weakens the fungal cell membrane, causing the cell contents to leak out, which kills the fungus.  This prevents the infection from spreading, relieving symptoms caused by the infection, including, itching and inflammation. 

What does Itrabond contain?

Itrabond capsules 100mg contain the active ingredient itraconazole a broad-spectrum antifungal drug, used to treat and prevent a variety of fungal infections.  The capsules are comprised of hard gelatin and contain itraconazole pellets.

Treating fungal infections with Itrabond

Itrabond capsules 100mg contain itraconazole, a broad-spectrum antifungal drug that is used to treat a wide range of superficial and systemic fungal infections, caused by a variety of susceptible fungal species.  Itrabond capsules 100mg specifically inhibit the synthesis of ergosterol, an important component of fungal cell membrane, which kills the fungus and stops it spreading; relieving the itching, scaling and other more severe symptoms caused by the fungal infection.  Fungal infections that can be treated with Itrabond 100 include:

  • Persistent infections of the skin with pityriasis versicolor, which caused by the yeast-like fungus malassezia and characterised by rash and patches of flaky skin on the trunk, neck or arms.
  • Persistent infections with the fungus tinea (also called ringworm) in various parts of the body including the body (tinea corporis), foot (tinea pedis) and groin (tinea cruris or jock itch).
  • Candidiasis (thrush) of the mucus membranes such as in the mouth and vagina, also of the skin.
  • Persistent infections of the vagina with the yeast candida (candidiasis).
  • Infection of the nail (onychomycosis) with yeast or dermatophyte fungi like tinea.
  • Fungal keratitis, an infection of the cornea of the eye by mould fungi like aspergillus or the yeast Candida, resulting in inflammation.
  • Systemic fungal infections that can affect internal organs such as histoplasmosis a rare systemic fungal infection from inhalation of a soil fungus into the lung causing flu-like symptoms; also aspergillosis, a lung infection caused by breathing in spores of the mould fungus Aspergillus.  These systemic fungal infections are more common in people who are immunocompromised.

Itrabond for thrush

Itrabond capsules 100mg contain itraconazole, a synthetic broad-spectrum antifungal agent that is used to treat a variety of fungal infections including thrush or candidiasis, which is caused by the yeast candida albicans.  Although any site on the body can become infected with candida, including the gastrointestinal tract, the most common site of infection are the mucous membranes of the mouth and vagina, with symptoms including creamy/white lesions or discharge and itching or irritation.  Itrabond capsules 100mg specifically inhibit the synthesis of ergosterol, an important component of fungal cell membrane, which kills the fungus and stops it spreading.  In this way Itrabond capsules 100mg relieves the symptoms of thrush in all its locations, and prevents constant reinfection in chronic recurrent vaginal thrush.

What are the side effects of Itrabond?

The most commonly reported side effects when taking Itrabond capsules 100mg include upset stomach, stomach cramps, nausea and vomiting, diarrhoea, skin rash, headache, constipation, dizziness, menstrual disorders.

When should Itrabond not be used?

You should not use Itrabond capsules 100mg if you:

  • are allergic to itraconazole or any ingredients in Itrabond
  • are pregnant or are breastfeeding, without discussion with your doctor
  • have kidney or liver disease
  • are taking medicines that interact with Itrabond, including, the antiviral rifampicin, rifabutin or zidovudine; terfenadine or astemizole for allergy, cisapride for reflux, the anticonvulsant phenytoin, the diuretic hydrochlorothiazide, medicines for diabetes such as glipizide, tolbutamide or glibenclamide, theophylline for asthma, the immunosuppressants tacrolimus and cyclosporine, some benzodiazepines such as midazolam, cholesterol lowering drugs like simvastatin and lovastatin, ergotamine for migraine or ergometrine to prevent bleeding after childbirth, the calcium channel blocker nisoldipine for high blood pressure and angina, the antibiotics clarithromycin and erythromycin, the antipsychotic pimozide

What medications interact with Itrabond?

Several medications interact with Itrabond capsules 100mg and should either not be taken while you are taking Itrabond or only after discussion and instruction from your doctor:

  • Drugs that cause a serious reaction with Itrabond: cisapride for reflux can cause heart problems
  • Drugs that affect Itrabond: the anticonvulsant phenytoin, the antiviral rifampicin, rifabutin or zidovudine; the diuretic hydrochlorothiazide, the antibiotics clarithromycin and erythromycin
  • Drugs that are affected by Itrabond: medicines for diabetes such as glipizide, tolbutamide or glibenclamide; theophylline for asthma, immunosuppressants tacrolimus and cyclosporine, some benzodiazepines such as midazolam, cholesterol lowering drugs like simvastatin and lovastatin, ergot alkaloids like ergotamine for migraine or ergometrine to prevent bleeding after childbirth, the calcium channel blocker nisoldipine for high blood pressure and angina, the antipsychotic pimozide

How should Itrabond be taken?

You should take your Itrabond capsules 100mg swallowed whole with a glass of water and with food once or twice daily depending on what you are being treated and on your doctor’s recommendations.  The dose you take and for how long depends on the type and severity of your infection and your doctor’s recommendations.  You should always finish your course of Itrabond 100, which may be for a few days or weeks, if not, the infection may not clear up completely.  

How long should you take Itrabond?

You should always finish your course of Itrabond 100, which may be for a few days or weeks, if not, the infection may not clear up completely.  

Missed dose of Itrabond

If you miss a dose of Itrabond capsules 100mg take it as soon as you remember, unless it is time to take the next dose, then skip the missed dose.  Do not take a double dose.

How should Itrabond be stored?

You should store your Itrabond capsules 100mg below 25°C in a cool dry place. 

Wysolone 5 (Prednisolone 5mg)

Wysolone general information

What is Wysolone used for?

Wysolone tablets 5mg are a steroid medication used in wide range of inflammatory, allergic and immune disorders to suppress clinical symptoms of the disease.  Amongst their many applications, Wysolone tablets 5mg are used to reduce inflammation in conditions where the immune system is overactive, like anaphylaxis, severe asthma, acute outbreaks of eczema and severe allergies; to reduce inflammation and suppress the immune system in autoimmune diseases like rheumatoid arthritis, systemic lupus erythematosus, ulcerative colitis or Crohn's disease, where the body’s immune system is directed against self, and to prevent rejection following organ transplant.  Wysolone 5 is also used as an anti-cancer medication along with other drugs, to treat certain tumours like leukemia and lymphoma, and to replace a lack natural corticosteroid cortisol in conditions where there is not enough produced, such as underactive adrenal glands or congenital adrenal hyperplasia, which can affect the ability of the body to regulate blood pressure, blood sugar, energy levels, normal development and protect against stress.

How does Wysolone work?

Wysolone tablets 5mg contain prednisolone, which is corticosteroid hormone and is a synthetic derivative of the natural glucocorticoid cortisol.  Prednisolone is the active metabolite of prednisone and can be converted from prednisone into prednisolone in the liver.  Prednisolone in Wysolone 5 acts directly through the glucocorticoid receptor that is expressed inside most cells of the body and regulates transcription of specific genes that control many aspects of development, metabolism and the immune response.  Prednisolone in Wysolone 5 has potent anti-inflammatory, anti-allergic, anti-rheumatic and immunosuppressant properties and has widespread effects acting on most tissues in the body to modify, glucose, fat, protein and calcium metabolism.  The major therapeutic actions of prednisolone are to reduce the vascular (blood vessels) and cellular inflammatory response primarily by blocking the production of inflammatory chemicals, like prostaglandins and leukotrienes, from inflammatory cells to reduce the swelling, redness and pain associated with inflammation; to modify the actions of cells involved in the allergic response, and to suppress the immune system to prevent rejection following organ transplant.  Prednisolone in Wysolone 5 also has anti-cancer properties and is used to prevent growth of certain tumours like leukemia and lymphoma. 

What does Wysolone contain?

Wysolone tablets 5mg contain the active ingredient prednisolone a potent synthetic corticosteroid used to treat a wide range of inflammatory, allergic and immune disorders.

What is the difference between prednisone and prednisolone?

Prednisone is an inactive drug precursor that must be converted to prednisolone in the liver to become active.  Prednisolone is particularly helpful for patients with liver problems who cannot metabolise prednisone into prednisolone in the liver.

Treating inflammation with Wysolone

Wysolone tablets 5mg contain prednisolone, which is a corticosteroid hormone and is a synthetic derivative of the natural glucocorticoid cortisol, with potent anti-inflammatory, anti-allergic, anti-rheumatic and immunosuppressant properties.  Wysolone 5 is used in a wide range of inflammatory disorders, to suppress clinical symptoms of the disease where inflammation is caused by many different factors.  For example, where the immune system is overactive, like severe asthma, acute outbreaks of eczema and severe allergies; autoimmune diseases, where the immune system is directed against self, like rheumatoid arthritis, systemic lupus erythematosus or Crohn's disease.  The anti-inflammatory actions of prednisolone in Wysolone tablets 5mg are to block the production of inflammatory chemicals, like prostaglandins and leukotrienes, from inflammatory cells which reduces the swelling, redness and pain associated with inflammation.   

What are the side effects of Wysolone?

The most commonly reported side effects when taking Wysolone 5 include: increased susceptibility to infection, muscle or bone aches and pains, weight gain, thinning of skin, bone demineralisation, slow wound healing, acne, redistribution of body fat creating the typical moon face, altered vision. Also behavioural and mood disturbances such as depression, irritability, anxiety, sleep disturbances.

What are the health risks of taking Wysolone?

Long term use of Wysolone 5 may cause the adrenal glands, which produce endogenous (naturally occurring) corticosteroids, to stop working efficiently.  This may slow down the growth rate in children and will need regular monitoring.  Wysolone 5 may also cause decreased bone mineral density, if used for long periods.  Long term use of steroids may be associated with a range of side effects such as round face, altered body shape, altered hair growth, thinning of the bones, decreased resistance to infection, increased salt and water retention, increased blood pressure and diabetes.

When should Wysolone not be used?

You should not use Wysolone 5 if you:

  • are allergic to prednisolone or any ingredients in Wysolone
  • are pregnant or are breastfeeding
  • have thyroid, stomach, heart, kidney or liver problems, high blood pressure, mood disorders, epilepsy, diabetes, glaucoma, osteoporosis
  • have any infectious disease, acute infection, systemic fungal infection, tuberculosis, uncomplicated viral hepatitis
  • are due to receive a vaccination with a live virus vaccine
  • are taking medicines that interact with Wysolone like anti-inflammatories such as; diclofenac, ibuprofen, mefenamic acidor naproxen; barbiturates, phenylbutazone, phenytoin or rifampicin, anticoagulants, insulin for diabetes
  • are taking diuretic medicines such as the thiazides or frusemide, these may cause increased loss of potassium when taken with Wysolone 5

What medications interact with Wysolone?

Several medications interact with Wysolone and should either not be taken while you are taking Wysolone or only after discussion and instruction from your doctor:

  • Drugs that cause a serious reaction with Wysolone: anti-inflammatories such as; diclofenac, ibuprofen, mefenamic acidor naproxen
  • Drugs that affect Wysolone: rifampicin, barbiturates, phenylbutazone, phenytoin
  • Drugs that are affected by Wysolone: live virus vaccine may be less effective, anticoagulants, insulin for diabetes

How should Wysolone be taken?

You should take your Wysolone tablets 5mg swallowed whole with a glass of water and with food.  The dose of Wysolone 5 that you take, how often and for how long depends on what you are being treated for and as recommended by your doctor.  You should continue to take your Wysolone 5 for as long as recommended by your doctor and should not stop taking them suddenly; withdrawal should be gradual to reduce risk of side effects.   

How long should you take Wysolone?

You should continue to take your Wysolone 5 for as long as recommended by your doctor and should not stop taking them suddenly; withdrawal should be gradual to reduce risk of side effects.   

Missed dose of Wysolone

If you miss a dose of Wysolone 5 take it as soon as you remember, unless it is time to take the next dose, then skip the missed dose.  Do not take a double dose.

How should Wysolone be stored?

You should store your Wysolone below 25°C in a cool dry place. 

 

 

Hyphoral 200mg (Ketoconazole)

Hyphoral general information

What is Hyphoral used for?

Hyphoral tablets 200mg are used to treat severe systemic fungal infections only in patients who cannot tolerate other treatments or where other treatments have failed and where the potential benefits are considered to outweigh the potential risks.  Hyphoral tablets 200mg are used for systemic fungal infections caused by inhalation of the spores of a soil fungus that can affect internal organs and cause influenza-like illness with fever, cough, headaches, skin rash, and myalgia (muscle pain), such as coccidioidomycosis caused by Coccidioides immitis, Blastomycosis, caused by Blastomyces dermatitidis and histoplasmosis caused by Histoplasma capsulatum.  Serious symptoms can develop including chronic lung infection and widespread infection reaching the bones, skin and urinogenital tract.  Hyphoral 200 is also used to treat chromomycosis, caused by penetration of the skin by a thorn or splinter and infection by several different fungal species that spread slowly through the skin.  Hyphoral tablets 200mg should not be used to treat fungal meningitis as the medication cannot penetrate into the nervous system. 

How does Hyphoral work?

Hyphoral tablets 200mg contain ketoconazole, a synthetic broad-spectrum antifungal agent that specifically kills the fungus by inhibiting the synthesis of ergosterol, an important component of fungal cell membrane that is not found in animal cells.  Ketoconazole in Hyphoral tablets 200mg weakens the fungal cell membrane, causing the cell contents to leak out which kills the fungus, preventing the infection from spreading and relieving symptoms caused by the fungal infection, including pain and inflammation.

What does Hyphoral contain?

Hyphoral tablets 200mg contain the active ingredient ketoconazole, a synthetic broad-spectrum antifungal used to treat severe systemic fungal infections.

Treating systemic fungal infection with Hyphoral

Hyphoral tablets 200mg contain ketoconazole, a synthetic broad-spectrum antifungal agent that is used to treat severe systemic fungal infections in patients who cannot tolerate other treatments or where other treatments have failed and where the potential benefits are considered to outweigh the potential risks.  These infections include coccidioidomycosis, histoplasmosis and blastomycosis, which are all caused by inhalation of spores produced by soil fungi.  Symptoms usually include influenza-like illness with fever, cough, headaches, skin rash, and myalgia (muscle pain), however, these infections can be difficult to treat and can affect internal organs causing serious symptoms including chronic lung infection and widespread infection reaching the bones, skin and urinogenital tract.  Ketoconazole in Hyphoral tablets 200mg inhibits the synthesis of ergosterol, an important component of fungal cell membrane that is not found in animal cells, which weakens the fungal cell membrane, causing the cell contents to leak out which kills the fungus, preventing the infection from spreading. 

What are the side effects of Hyphoral?

The most commonly reported side effects when taking Hyphoral include: upset stomach, stomach cramps, nausea and vomiting, diarrhoea or constipation, headache, rash, dizziness, tingling sensations, sensitivity to light, erectile dysfunction, swelling of the breast.

What are the risks of using of Hyphoral?

Ketoconazole in Hyphoral tablets 200mg can cause serious liver toxicity and can result in the need for liver transplant or be fatal.  Liver function should therefore be checked before and during treatment with Hyphoral tablets 200mg.  Symptoms of liver toxicity include: nausea, vomiting feel tired, stomach pain or tenderness, weight loss, or loss of appetite, dark urine or light coloured stools, yellowing of the skin or the whites of the eyes, fever or rash.  Ketoconazole in Hyphoral tablets 200mg can also cause QT prolongation due to changes in the electrical activity of the heart, which can cause irregular heart beat and can be life threatening

When should Hyphoral not be used?

You should not use Hyphoral tablets 200mg if you:

  • are allergic to ketoconazole or any ingredients in Hyphoral
  • are pregnant or are breastfeeding
  • have liver disease or are recovering from hepatitis as there is a risk of serious liver damage
  • have adrenal insufficiency
  • have had an abnormal heart rhythm tracing (ECG) or anyone in your family have or have had a heart problem called “congenital long QT syndrome
  • drink alcohol, as this may make you feel sick or cause headache in combination with ketoconazole
  • are taking medicines that interact with Hyphoral, including terfenadine, mizolastine or astemizole for allergy, halofantrine for treating malaria, cisapride for reflux, statins for cholesterol lowering (simvastatin, atrovastatin lovastatin) pimozide for mental disorders, calcium channel blockers (bepridil, epleronone, nisoldipine) for angina and high blood pressure, medicines containing ergot alkaloids such as ergotamine, antiarrhythmic drugs for irregular heat beats (quinidine, disopyramide and dofetilide), irinotecan for cancer chemotherapy

What medications interact with Hyphoral?

Several medications interact with Hyphoral tablets 200mg and should either not be taken while you are taking Hyphoral or only after discussion and instruction from your doctor:

  • Drugs that cause muscle problems with Hyphoral: the cholesterol lowering statins simvastatin, atrovastatin and lovastatin.
  • Drugs that prolong the QT interval with with Hyphoral: pimozide for mental disorders, cisapride for reflux, methadone, the antiarrhythmics disopyramide, dofetilide, dronedarone, and ranolazine, medicines containing ergot alkaloids such as ergotamine
  • Drugs that affect Hyphoral: ritonavir for HIV, anticonvulsants like phenytoin and carbamazepine, anti-infectives like rifampicin, nevirapine, isoniazid and rifabutin
  • Drugs that are affected by Hyphoral: triazolam, midazolam, or alprazolam, halofantrine for treating malaria, terfenadine, mizolastine or astemizole for allergy, calcium channel blockers (bepridil, epleronone, nisoldipine) for angina and high blood pressure, irinotecan for cancer chemotherapy

How should Hyphoral be taken?

You should take your Hyphoral tablets 200mg swallowed whole with a glass of water and with food once a day.  You should continue to take your Hyphoral tablets 200mg for 5-10 days or up to several months, depending on what you are being treated for and your doctor’s recommendations.  Always finish your course of tablets even if you feel better, if not, the infection may not clear up completely.  Do not take medicines that neutralise stomach acid within 2 hours of taking Hyphoral 200mg tablets, as sufficient stomach acid is required for ketoconazole to be absorbed and do not drink any alcohol while taking Hyphoral tablets 200mg.

How long should you take Hyphoral?

You should continue to take your Hyphoral tablets 200mg for 5-10 days or up to several months, depending on what you are being treated for and your doctor’s recommendations. 

Missed dose of Hyphoral

If you miss a dose of Hyphoral tablets 200mg take it as soon as you remember, unless it is time to take the next dose, then skip the missed dose.  Do not take a double dose.

How should Hyphoral be stored?

You should store your Hyphoral tablets 200mg below 25°C in a cool dry place.  

All medicines have risks and benefits, and individual results may vary. Only purchase medicines from this site in accordance with the advice you have obtained from an appropriate medical professional.
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