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Generics

Our Generics section contains a wide range of medications that are generic versions of brand name products across various therapeutic areas, and sub-categories are based on these therapeutic areas.

The different classes of Generic medication are listed on the left of the page and when you click on one of these, the generic alternatives to brand name products display.

Use the search feature to quickly find the product you are looking for, by entering either the active ingredient, e.g. Efavirenz or the product name, e.g. Efavir. 

Our Generics - AIDS/HIV medications provide a range of cost-effective generic medicines known as antiretrovirals.  These are used to treat infection with Human Immunodeficiency Virus (HIV), to help relieve symptoms and prevent progression to acquired immune deficiency syndrome (AIDS).

You can search for the product you want using the search box, by entering either the active ingredient, e.g. efavirenz or the product name, e.g. Efavir.

What is AIDS?

Human Immunodeficiency Virus (HIV) is an RNA virus (known as a retrovirus) that specifically attacks the immune system, which affects your ability to fight other infections.  HIV infects CD4 cells, which are white blood cells that play an essential role in the immune response to infection.  Without treatment, the virus multiplies and spreads, and the amount of virus in your body increases, while at the same time, the number of CD4 cells decreases.  Eventually, the immune system becomes severely damaged and is unable to fight infection, leading to an increased risk of opportunistic infection, which is an infection that the body usually can fight when not immunocompromised.  This stage of HIV infection is called Acquired Immune Deficiency Syndrome (AIDS) and is potentially life-threatening. 

How do antiretrovirals work?

Antiretrovirals are used to treat HIV infection, and are designed to prevent the replication of the virus.  The aim of antiretroviral treatment is to reduce the amount of virus in the body (viral load) down to a low level and prevent the spread of HIV.  Antiretrovirals do not kill the virus.  Once HIV replication is reduced, the numbers of CD4 cells can increase, so that the immune system can recover, and further damage is prevented.  Antiretroviral therapy uses a combination of different drugs that work by attacking a different stage of the viral replication process.  Using a combination of drugs reduces the risk of the virus becoming resistant.  Some of these combination medications are supplied as a single tablet containing a fixed dose of two or three drugs.

Types of antiretroviral drugs include:

  • Reverse transcriptase (RT) inhibitors.  RT is a virus-specific enzyme needed for HIV replication.  There are two types of RT inhibitor that work by different mechanisms:
    • nucleoside analogue reverse transcriptase inhibitor (NRTI), such as tenofovir and zidovudine
    • non-nucleoside reverse transcriptase inhibitor (NNRTI), such as efavirenz and nevirapine. 
  • The viral protease enzyme is another drug target.  This enzyme is needed to allow the mature active virus to be released and infect new cells.  These drugs include ritonavir and indinavir.
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Our Antidepressants sub-category contains cost-effective generic medicines used to treat symptoms of depression and other mood disorders like anxiety and bipolar disorder. 

You can search for the product you want using the search box, by entering either the active ingredient, e.g. fluoxetine, or the product name, e.g. Elevat. 

Branded Product
Generic Alternative

What is depression?

Depression is not just feeling low, which we all feel from time to time.  It is a long term feeling of sadness that persists for more than a few weeks and affects your behaviour and quality of life.  Depression is an illness, which can range from mild to severe depending on your symptoms.  These symptoms include anxiety, loss of interest in your usual activities, disturbed sleep, change in appetite, fatigue, feelings of worthlessness or guilt, difficulty thinking or concentrating, and recurrent thoughts of suicide.  This condition is also called Major Depressive Disorder and is one of several mood disorder treated by antidepressants.  Other mood disorders include anxiety disorder, bipolar disorder, obsessive-compulsive disorder (OCD), panic disorder and post-traumatic stress disorder (PTSD).

Depression and other mood disorders are thought to be due to an imbalance of brain chemicals called neurotransmitters, particularly serotonin and noradrenaline.  These brain chemicals pass messages between nerve cells (neurones) in the area of the brain that regulates mood.  When a neurotransmitter is released by one neurone, it passes across the gap between neurones (synapse) and triggers an electrical impulse in the next neurone.  Transmission of a nerve signal from one neurone to another allows nerve cells to communicate with each other.  Any neurotransmitter remaining in the synapse after release from the first nerve cell (pre-synaptic) and not used by the receiving nerve cell (post-synaptic), is taken up back into the pre-synaptic neurone.  This process is called neurotransmitter reuptake.

How do antidepressants work?

Antidepressants are medications that are used to treat symptoms of depression and other mood disorders.  They are classed according to how they work and which brain chemicals they target.  These include:

  • Selective serotonin reuptake inhibitors (SSRI) such as fluoxetine, escitalopram, and sertraline.
  • Serotonin noradrenaline reuptake inhibitors (SNRI) such as venlafaxine.
  • Tricyclic antidepressants, such as imipramine, and tetracyclic antidepressants such as trazodone, are non-selective neurotransmitter reuptake inhibitors as well as blocking effect of other neurotransmitters like histamine and acetylcholine.
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Our Cholesterol-Lowering medications contain cost-effective branded medicines and generic alternatives that are used to lower high blood cholesterol (hypercholesterolaemia) and triglycerides (a type of fat that is stored in fat cells) to reduce risk of cardiovascular disease.

You can search for the product you want using the search box, by entering either the active ingredient, e.g. atorvastatin or the product name, e.g. Lipitor.

Why is high cholesterol a health problem?

Cholesterol is a fat that is produced by the liver but also comes from our diet.  We all need some cholesterol for normal body functions, such as making cell membranes, producing and transporting hormones, and building protective nerve sheaths.  Eating a lot of fatty foods in your diet can increase your blood cholesterol levels above healthy levels.  Since cholesterol is not water-soluble, it circulates in the blood attached to proteins called lipoproteins.  Excess cholesterol is deposited in the arteries causing them to become blocked and hardened, which narrows the arteries and restricts blood flow.  This condition, called atherosclerosis, increases your risk of developing cardiovascular disease, including heart attack, angina, and stroke.

How do cholesterol-lowering medications work?

Cholesterol-lowering medications are used to reduce high cholesterol and triglyceride levels.  They are classed according to how they work and include:

  • Statins that block the production of cholesterol by the liver but have no effect on dietary cholesterol, such as atorvastatin, simvastatin, and rosuvastatin
  • Cholesterol absorption inhibitors that block the absorption of cholesterol in the intestines, such as ezetimibe
  • Fibrates that regulate the amount of lipoprotein produced to carry cholesterol in the blood, such as fenofibrate
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Our diabetes medications contain cost-effective generic alternatives to branded medicines that are used to improve control of blood sugar levels.  This reduces the risk of heart attack, stroke, and damage to small blood vessels that supply the eyes, kidneys, and brain. 

You can search for the product you want using the search box, by entering either the active ingredient, e.g. metformin or the product name, e.g. Cetapin.

What is diabetes?

Diabetes is a condition where blood sugar levels (glucose) are too high and difficult to control.  Insulin, produced by the pancreas, is the main blood glucose regulating hormone.  It ensures that there is enough glucose needed for energy throughout the body, particularly the brain.  Glucose is produced in the liver and also absorbed from the diet.  Excess glucose is stored in the liver and muscles.  Hyperglycaemia is when too much glucose circulates in the blood, either because your body does not make enough insulin or has become resistant to the effects of insulin. 

Diabetes exists in two forms. Type 1 diabetes is usually hereditary, develops early in life, and is caused by damage to the pancreas due to attack by the body’s immune system.  Type 2 diabetes usually begins later in life and is related to lifestyle factors, including obesity, poor diet, smoking, and lack of exercise.

Diabetes increases the risk of serious health complications caused by damage to blood vessels.  Damage to large blood vessels like arteries (macrovascular) can cause cardiovascular disease resulting in heart attack and stroke.  Damage to small blood vessels like capillaries (microvascular) can cause kidney failure (diabetic nephropathy), and eye damage with loss of vision (diabetic retinopathy).  Damage to nerves (diabetic neuropathy) can result in amputation, particularly of the toes.

How do diabetic medications work?

Diabetic medications that are taken as tablets are known as oral antihyperglycaemics and are classed according to how they work.  They should be used alongside improving diet and increasing exercise and they include:

  • Biguanides like metformin improve your body’s response to the effects of insulin, increase the amount of glucose that is stored, and reduce the amount of glucose produced in the liver and absorbed from the diet.
  • Acarbose inhibits the action of the enzyme alpha-glucosidase that converts carbohydrates in the diet to simple sugars like glucose, and this reduces the amount of glucose that enters the blood after a meal.
  • Thiazolidinediones like rosiglitazone and pioglitazone reduce insulin resistance by increasing the body’s response to insulin and acting directly on cells of the liver, muscle, and fat tissue.
  • Sulphonylureas like glipizide increase insulin production by directly stimulating the pancreatic beta cells to produce more insulin.
  • Gliflozins like empagliflozin and canagliflozin act directly on the kidneys to inhibit glucose reabsorption from the urine back into the blood, to lower blood glucose levels.
  • DPP-4 inhibitors like sitagliptin work by inhibiting the enzyme dipeptidyl peptidase 4 (DPP-4) and preventing the destruction of incretins, which are small proteins released from the intestine after a meal that stimulate insulin production and reduce glucose production by the liver. 
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Our Heart Meds products contain cost-effective generic alternatives for many branded medicines that are used to treat cardiovascular disease to reduce the risk of heart attack and stroke.

You can search for the product you want using the search box, by entering either the active ingredient, e.g. enalapril or the product name, e.g. Acetec.

Branded Product
Generic Alternative

Cardiovascular disease

Cardiovascular disease covers a range of heart and circulation problems that can increase the risk of heart attack and stroke.  These include:

  • high blood pressure (hypertension) can damage your artery walls and increase stress on your heart, as well as increasing pressure on smaller blood vessels, such as those in the kidneys, which can lead to kidney damage. 
  • heart failure, which is when the heart muscle is weakened and cannot pump blood efficiently.
  • coronary heart disease when arteries of the heart become blocked and hardened.
  • angina causing shortness of breath chest pain due to reduced oxygen supply to the heart muscle.
  • Atherosclerosis, which is when cholesterol is deposited in the arteries causing them to become narrowed and hardened.

A heart attack is caused by restricted blood flow to the heart muscle, resulting in heart muscle cell damage.  A stroke is the result of a blockage in a blood vessel in the brain or a bleed into the brain, which can cause brain cells to die if not treated quickly. 

Risk factors for cardiovascular disease include having high blood cholesterol levels, lifestyle factors like obesity and smoking, and conditions like diabetes. 

Medications for cardiovascular conditions and how they work

We sell a wide range of generic Heart Meds, which are classed according to how they work.  Some of these medications are used only for a specific condition, but others can be used for several conditions.  For some conditions, more than one class of heart medication can be used together for increased effectiveness.

Our generic Heart Meds include:

  • ACE inhibitors like enalapril and ramipril are used to treat hypertension and congestive heart failure.  They work by inhibiting the action of Angiotensin-Converting Enzyme, which relaxes and widens blood vessels, reduces blood volume, lowers blood pressure, and helps the heart to pump more efficiently relieving symptoms of heart failure. 
  • Angiotensin II receptor blockers (ARB) like valsartan and losartan, are used to treat hypertension and congestive heart failure.  They work by blocking the hormone angiotensin II binding to its receptor, which relaxes and widens blood vessels, reduces blood volume, lowers blood pressure, and helps the heart to pump more efficiently, relieving symptoms of heart failure.
  • Calcium channel blockers like diltiazem, amlodipine, and felodipine, are used to treat hypertension and angina.  They work by blocking calcium ions entering smooth muscle cells of blood vessel walls, allowing blood vessels to relax and widen.  
  • Diuretics like the hydrochlorthiazide torsemide, are used to treat hypertension and congestive heart failure.  They work by acting on the kidneys to promote the removal of salts and water from the blood, which reduces blood volume, lowers high blood pressure, and helps remove fluid retention in the tissues (oedema).
  • Anti-clotting drugs like clopidogrel are used to prevent blood clot formation (thrombosis).  They work by inhibiting platelet aggregation, which reduces the risk of a clot forming in the arteries that can cause heart attack or stroke if it travels to the heart or brain.
  • Vasodilators like minoxidil are used to treat poor circulation, hypertension and angina.  They act directly on blood vessel walls, causing them to relax and widen, which allows blood to flow more freely.
  • Beta blockers like propranolol and atenolol are used to treat hypertension, angina and arrhythmias (heart rhythm disorders).  They work by blocking the action of certain hormones like adrenaline that act on beta receptors in the heart, which slows the heart rate, widens blood vessels, lowers blood pressure, and increases blood flow and oxygen supply to the heart.  
  • Antiarrhythmics like amiodarone are used to treat heart rhythm disorders, including irregular heartbeat (arrhythmia) and rapid heartbeat (tachycardia).  They work by correcting the abnormal electrical activity in the heart. 
  • Heart rate lowering drugs called cardiotonic drugs like ivabradine are used to treat coronary artery disease, which is narrowing of blood vessels that supply the heart.  They work by acting directly on the heart muscle to reduce the heart rate.
  • Anti-angina drugs like ranolazine are used to treat chronic stable angina, which is a symptom of heart disease.  They work by acting directly on the heart muscle to slow down the rate of muscle contraction, which reduces the need for oxygen and relieves symptoms of angina.
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Our Infections class of Generics medications are used to treat a range of infections including bacterial, viral, fungal; also parasitic infections like malaria transmitted by mosquito bites and the intestinal parasitic tapeworm.

Use the search feature to quickly find the product you are looking for, by entering either the active ingredient, e.g. Amoxycillin or the product name, e.g. APO-Amoxi.
Branded Product
Generic Alternative