Our Thyroid group of Pet Care products contains a drug for treating hyperthyroidism, which is overactive thyroid in cats and dogs.
gland consists of 2 small lobes situated in the neck around the trachea
gland produces two hormones; calcitonin, which regulates calcium metabolism and
thyroid hormone, which controls many important body functions, including how
the body uses energy, regulates temperature, metabolises nutrients, and
controls growth and development.
hormone exists in two forms. Thyroxine
or levothyroxine, also known as T4 and liothyronine or L-triiodothyronine also
known as T3. Up to 90% of thyroid hormone
secreted by the thyroid gland is T4, which is inactive but is converted to the
active form of thyroid hormone T3 when it reaches its target tissue. This
conversion takes place in the liver, kidney and other tissues of the body and
T3 then interacts with a specific receptor inside the nucleus of cells, to
influence the transcription of specific pieces of DNA (genes) to produce
proteins needed to manage and control a variety of processes, including
carbohydrate, fat, protein and vitamin metabolism.
Hyperthyroidism or thyrotoxicosis, as it is also known, is a common disorder in cats, particularly older cats and is caused by overproduction of thyroid hormone usually due to a benign enlargement of the thyroid gland. However, hyperthyroidism is a rare condition in dogs and is usually caused by a malignant tumour called thyroid adenocarcinoma.
The enlarged thyroid gland in cats is similar to toxic nodular goitre in humans, which is one of the major causes of hyperthyroidism in humans. The symptoms or signs of hyperthyroidism in cats can be dramatic and can cause serious illness. They include:
Although surgical removal of the affected thyroid tissue is an option for treating hyperthyroidism (thyroidectomy); also radioactive iodine treatment, medical treatment is available and successful. Anti-thyroid drugs known as thioamides like carbimazole are widely used to treat hyperthyroidism in animals and humans. They work by blocking the synthesis of thyroid hormone and help restore high levels of thyroid hormone to normal levels.