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Microgynon 50ED 84 Tablets/Pack
Levonorgestrel 0.125mg/Ethinylestradiol 0.05mg
Bayer Schering Pharma
Oral contraceptive (oestrogen plus progestagen)
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Microgynon general information
What is Microgynon used for?
Microgynon 50 ED is a low dose combined oral contraceptive pill and is used as an effective means of birth control to prevent unwanted pregnancy. Microgynon 50 ED contraceptive pills contain a combination of two hormones at low doses in a single pill. Each pack of Microgynon 50 ED contains one month’s supply of pills of which there are 21 hormone-containing pills and 7 placebo (non-hormonal) pills, to allow each monthly cycle to end with a withdrawal bleed. When using Microgynon 50 ED for contraception, you will probably find that your periods become more regular and you may also experience lighter, less painful menstruation and an improvement in pre-menstrual symptoms, like bloating, swelling or weight gain related to fluid retention; Microgynon 50 ED also helps improve in acne and reduces greasiness of the skin and hair.
How does Microgynon work?
Microgynon 50 ED contraceptive pills contain a combination of two hormones, ethinyloestradiol, a synthetic oestrogen, and levonorgestrel, a synthetic progestogen, which work together to protect against unwanted pregnancy. Preparation for pregnancy depends on a complex interaction between the female sex hormones produced by the ovaries; oestrogen, which stimulates ovulation, and progesterone which prepares the endometrium (lining of the uterus) for implantation of an embryo; as well as other regulating hormones, produced by the hypothalamus in the brain and the pituitary gland. Microgynon 50 ED combined hormonal contraception works by disrupting the normal menstrual cycle, preventing egg maturation and suppressing ovulation, as well as preventing development of the endometrium, so that a fertilised egg would not be able to implant and grow. Another contraceptive action of Microgynon 50 ED pills is that the cervical mucus, which normally changes consistency at ovulation to become thinner, remains thick, forming a physical barrier to sperm. Some synthetic progestogens have androgenic activity, but levonorgestrel in Microgynon 50 ED, has very weak androgenic activity, which has a beneficial effect on androgen-related skin disorders such as acne and hirsutism (unwanted hair).
What does Microgynon contain?
Microgynon 50 ED contraceptive pills contain the active ingredient combination of two hormones, ethinyloestradiol (0.05 mg), a synthetic oestrogen, and levonorgestrel (0.325 mg), a synthetic progestogen, which work together to protect against pregnancy. They also contain lactose monohydrate, maize starch, povidone 25 000, magnesium stearate, sucrose, povidone 700 000, macrogol 6000, calcium carbonate, purified talc, glycerol 85%, ferric oxide pigment (yellow), titanium dioxide, montanglycol wax. In each pack there are 21 hormone-containing pills and 7 placebo (non-hormonal) pills.
Taking Microgynon for contraception
Microgynon 50 ED contraceptive pills contain a combination of two hormones, ethinyloestradiol, a synthetic oestrogen, and levonorgestrel, a synthetic progestogen, which work together to provide effective birth control by protecting against pregnancy. Microgynon 50 ED contraceptive pills work by preventing egg maturation and suppressing ovulation, as well as preventing development and thickening of the endometrium (lining of the uterus) in preparation for implantation, so that a fertilised egg would not be able to implant and grow. You must take your Microgynon 50 ED contraceptive pills continually to ensure effective contraception, with 21 days of hormonal pills followed by 7 days non-hormonal pills, during which time you will have a menstrual bleed, which may be light and less painful than usual.
Can you get pregnant if you miss a Microgynon pill?
Microgynon 50 ED contraceptive pills provide effective contraception when taken correctly and have a failure rate of approximately 1% per year. The failure rate may increase if you miss a pill and may result in an unwanted pregnancy. To prevent this ensure that you take your Microgynon 50 ED contraceptive pills correctly and continually.
What are the side effects of Microgynon?
The most frequently reported side effects when taking Microgynon 50 ED contraceptive pills are: breast tenderness, breast pain, abdominal pain, nausea, oedema, and headache, skin rash and itching, insomnia and depression. Less common side effects include: migraine, fluid retention, changes in body weight, changes in libido.
When should Microgynon not be used?
You should not use Microgynon 50ED if you:
- are allergic to ethinyloestradiol or levonorgestrel or any of the ingredients in Microgynon 50 ED contraceptive pills
- have a past or family history of carcinoma of the breast, endometrial carcinoma or liver disease
- have high blood pressure, lipid disorders or migraine
- have had deep venous thrombosis, thromboembolic disorders, heart attack or stroke
- have diabetes with changes to the blood vessels
- abnormal genital bleeding of unknown cause
- are pregnant or planning to become pregnant
- are diabetic and taking Microgynon 50 ED contraceptive pills your glucose tolerance may be affected and you may need to discuss using other antidiabetic drugs with your doctor
- are taking other medications that may interact with Microgynon 50 ED, such as anticonvulsants like phenytoin and carbamazepin, barbiturates, anti-infectives like rifampicin, rifabutin, nevirapine, the antifungal griseofulvin, antibiotics like penicillin, preparations containing St John's Wort
What medicines interact with Microgynon 50 ED?
Some medications interact with Microgynon 50 ED contraceptive pills and prevent them working effectively, increasing your risk of becoming pregnant. If you are taking any of the following you may need to take other contraceptive precautions:
- anticonvulsants like phenytoin and carbamazepin
- anti-infectives like rifampicin, rifabutin, nevirapine, griseofulvin
- antibiotics like penicillin
- preparations containing St John's Wort
What are the health risks of Microgynon 50 ED?
Combination contraceptive pills like Microgynon 50 ED can increase risk of thrombosis (blood clots), which can have serious consequence depending on where the clot forms. There is also an increased risk of breast cancer.
How should Microgynon be taken?
Each pack of Microgynon 50 ED contraceptive pills contains 28 pills for a complete monthly cycle and should be taken continually to ensure effective contraception. The first 21 pills contain the contraceptive hormones and the last 7 pills are a placebo, which do not contain any hormones. While you are taking these placebo pills you will have a menstrual bleed. When you have finished one pack, start a new one the next day. If you have gastrointestinal problems like vomiting or diarrhoea within 3-4 hours of taking your hormonal pill, this is the same as missing a pill and you should take other contraceptive precautions for the next 7 days.
How long should you take Microgynon?
Each pack Microgynon 50 ED contraceptive pills contains 28 pills for a complete monthly cycle and should be taken continually to ensure effective contraception. You should take Microgynon 50 ED contraceptive pills for as long as your doctor recommends.
Missed dose of Microgynon
If you miss a dose of Microgynon 50 ED follow these guidelines to help you decide what to do:
Weeks 1 to 3 (yellow hormonal pills)
- If you are less than 12 hours late in taking your pill, take it as soon as you remember and take the next one at your usual time. You are still protected against pregnancy.
- If you are more than 12 hours late in taking your pill, take the last tablet as soon as you remember and take the next one at your normal time, which may mean taking 2 tablets in one day. Contraceptive protection may be reduced and you are at risk of becoming pregnant, unless you take other contraceptive precautions for the next 7 days.
Week 4 (white non-hormonal pills)
Take the next pill as usual and discard the missed pill. You are not at risk of becoming pregnant.
How should Microgynon be stored?
Keep your Microgynon 50 ED contraceptive pills in their calendar pack until use. Store at room temperature below 25°C.