Rifaclean (Rifaximin 550mg)
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Rifaclean (Rifaximin 550mg) 10 Tablets/Strip
Also known as Xifaxan
Antibiotic (rifamycin, gastrointestinal)
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Rifaclean tablets 550mg contain rifaximin a locally-acting antibiotic that is used to treat hepatic encephalopathy caused by build-up of toxins produced by certain intestinal bacteria.
Rifaclean general information
What is Rifaclean used for?
Rifaclean tablets 550mg are an antibiotic used to treat hepatic encephalopathy (HE) to prevent its recurrence, where other treatments have failed or are contraindicated. HE is a neuropsychiatric condition in which there is a loss of brain function due to liver damage, such as cirrhosis. This results in a build-up of toxins like ammonia in the blood, which causes symptoms including confusion, difficulty thinking, loss of fine hand movements, behaviour changes and a musty or sweet smelling breath. It is thought that an imbalance of the intestinal microbiota (good versus bad bacteria) with a higher proportion of harmful bacteria, may contribute to the pathogenesis of several diseases including liver cirrhosis. Rifaclean is effective against a wide range of intestinal bacteria, including those like Streptococcus salivarius that produce ammonia. Ammonia is a toxin that a healthy liver would convert into urea which is then excreted in the urine, but in a damaged liver this process is impaired. Rifaclean tablets 550mg help restore the balance in the composition of intestinal bacteria and reduce risk of HE and its recurrence1. Rifaclean cannot be used to treat other infections as it is not absorbed into the blood and therefore, only acts locally in the gastrointestinal tract to kill local bacteria.
How does Rifaclean work?
Rifaclean tablets 550mg contain rifaximin, a locally acting antibiotic belonging to the rifamycin class of antibiotics. It is a non-systemic antibiotic, which means it acts locally in the intestines and is not absorbed into the circulation. Rifaximin in Rifaclean 550 works by binding to the bacterial enzyme DNA-dependent RNA polymerase and this action inhibits bacterial RNA synthesis. This prevents RNA transcription and thereby the production of bacterial proteins, which inhibits growth of the bacteria. Rifaximin in Rifaclean 550 is effective against bacteria that break down proteins in the intestines by the process of deamination resulting in ammonia production, reducing the high blood levels of ammonia that contribute to the pathogenesis of hepatic encephalopathy2-5.
What does Rifaclean contain?
Rifaclean tablets 550mg contain the active ingredient rifaximin, a locally acting antibiotic used to prevent the recurrence of hepatic encephalopathy where other treatments have failed or are contraindicated. Rifaclean also contains the following inactive ingredients: Mannitol, Croscarnelose sodium, Maize starch, Polyvinyl pyrrolidone, Propylene glycol, Pregelatinised starch, Microcrystalline cellulose 200, Colloidal silicon dioxide, Talc, Magnesium stearate, Wincoat WT-QCAQ-OI060-Orange.
Rifaclean for hepatic encephalopathy
Rifaclean tablets 550mg contain rifaximin, a locally acting antibiotic that is used to treat hepatic encephalopathy to prevent its recurrence where other treatments have failed or are contraindicated. Hepatic encephalopathy is a neuropsychiatric condition in which there is a loss of brain function due to liver damage, such as cirrhosis. This results in a build-up of toxins in the blood, such as ammonia which causes symptoms including confusion, difficulty thinking, loss of fine hand movements, behaviour changes and a musty or sweet smelling breath. Rifaximin in Rifaclean 550 is effective against bacteria that break down proteins in the intestines by deamination resulting in ammonia production. A healthy liver would normally convert ammonia into urea which is then excreted in the urine, but in a damaged liver this process is impaired. Rifaximin in Rifaclean inhibits growth of ammonia producing bacteria, reducing the high blood levels of ammonia that contribute to the pathogenesis of hepatic encephalopathy.
What are the side effects of Rifaclean?
The most commonly reported side effects when taking Rifaclean tablets 550mg include dizziness, headache, fever, fatigue, abdominal pain, constipation, defecation urgency, diarrhoea, flatulence, bloating and distension, nausea and vomiting, oedema, rash. Rifaclean can result in Clostridium difficile-associated diarrhoea (CDAD), which is a more serious form of diarrhoea ranging in severity from mild to life-threatening and is due to the changes in intestinal flora that happens when taking antibiotics.
When should Rifaclean not be used?
You should not use Rifaclean tablets 550mg if you:
- are allergic to rifaximin or any ingredients in Rifaclean
- are pregnant or are breastfeeding
- have severe liver disease, without discussion with your doctor
- have any form of intestinal obstruction
- are taking medicines that interact with Rifaclean, including other rifamycin antibiotics and the immunosuppressant ciclosporin. Rifaclean reduces the effect of warfarin
How should Rifaclean be taken?
For hepatic encephalopathy you should take your Rifaclean tablets 550mg swallowed whole with a glass of water with or without food twice daily for 6 months. The dose you take should be as recommended by your doctor. You should only continue to take your Rifaclean beyond 6 months based on your doctor’s recommendation, after evaluation by your doctor of how well you are responding and any side effects you are experiencing.
How long should you take Rifaclean?
You should only continue to take your Rifaclean tablets 550mg beyond 6 months based on your doctor’s recommendation, after evaluation by your doctor of how well you re responding and any side effects you are experiencing.
Missed dose of Rifaclean
If you miss a dose of Rifaclean tablets 550mg take it as soon as you remember, unless it is time to take the next dose, then skip the missed dose. Do not take a double dose.
How should Rifaclean be stored?
You should store your Rifaclean tablets 550mg below 25°C in a cool dry place.
- Ponziani FR, Gerardi V, Pecere S, D'Aversa F, Lopetuso L, Zocco MA, Pompili M, Gasbarrini A. Effect of rifaximin on gut microbiota composition in advanced liver disease and its complications. World J Gastroenterol. 2015 Nov 21;21(43):12322-33.
- Zeng X, Tang XJ, Sheng X, Ni W, Xin HG, et al. Does low-dose rifaximin ameliorate endotoxemia in patients with liver cirrhosis: a prospective study. J Dig Dis 2015 Nov;16(11):665-74.
- Shayto RH, Abou Mrad R, Sharara AI. Use of rifaximin in gastrointestinal and liver diseases. World J Gastroenterol. 2016 Aug 7;22(29):6638-51.
- Peleman C, Camilleri M. Rifaximin, Microbiota Biology, and Hepatic Encephalopathy. Clin Transl Gastroenterol 2016 Oct 6;7(10):
- Iadevaia MD, Del Prete A, Cesaro C, Gaeta L, Zulli C, Loguercio C. Rifaximin in the treatment of hepatic encephalopathy. Hepat Med 2011; 3: 109–117.